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By Vidya Bhushan Gupta

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Further, the clinical diagnosis of ASD may have more to do with the ability and willingness to make an ASD diagnosis than with the true onset of pathology. In fact, much neuropathological evidence supports a prenatal origin (7). The second reason why autism prevalence trends are often used to infer trends in incidence is that when the average duration of a disease is unchanging, trends in prevalence will approximate trends in incidence. For a lifelong condition with no cure that is not strongly associated with premature mortality, like autism, the average duration of disease is not expected to change drastically with time.

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American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: APA; 1994. Copyright © 2004 Marcel Dekker, Inc. 38 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. Karapurkar et al. World Health Organization. International Statistical Classification of Diseases and Related Health Problems. 10th revision, Clinical Modification, ICD-10. Geneva, Switzerland: World Health Organization, 1992. McCarthy P, Fitzgerald M, Smith M.

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