Download Biomanufacturing by Homare Tabata (auth.), Jian-Jiang Zhong (eds.) PDF

By Homare Tabata (auth.), Jian-Jiang Zhong (eds.)

Advances in bioproducts production corresponding to the creation of the anticancer drug paclitaxel through large-scale plant mobilephone tradition, submerged cultivation of medicinal mushrooms, and monoclonal antibody creation are mirrored. Interactions between molecular, mobile and technique engineering facets in commercial fermentations are mentioned, and alertness of fuzzy regulate and fuzzy neural networks to useful construction and the biomedical region are proven. For sustainable improvement and eco-friendly processing, construction of lactic acid from paper sludge, creation of a time-honored fermentation feedstock from wheat, and fabrication and alertness of whole-cell established biosensors within the atmosphere also are demonstrated.

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44 46 47 49 51 52 54 54 55 . . . . . . . . . . . . . . . 57 . . . . . . . . . . . . . . . . 58 1 Introduction The number of types of mushroom on Earth is estimated at 140,000, yet maybe only 10% (approximately 14,000 named species) are known, of which 2000 are estimated to be edible; few have been studied thoroughly from the standpoint of their commercial potential. Less than 25 species of mushrooms are accepted widely as food and only very few species have attained the level of an item of commerce.

The rate of consumption of glucose was also lower in this case than in the other three cases [8]; in all experiments the residual sugar was completely utilized before day 16. The cell yield on glucose (calculated between day 4 and the time of maximum biomass) was doubled by static cultivation. It suggests that sugar utilization might be more efficiently shifted to biomass formation in static cultures. In Figs. 7B and 7C, time profiles of GA formation in static culture are compared with the shaking cultivation (as the control).

2 Effect of oxygen supply . . . . . . . . . . . . 29 Effect of shear stress . . . . . . . . . . . . . 34 5 Strategies for enhancing metabolite production: fed-batch cultivation and two-stage cultivation . . . . . . 2 Fed-batch cultivation . . . . . . . . . . . Fed-batch cultivation in shake flasks . . . . . . Batch and fed-batch cultivation in stirred bioreactors . . Enzyme activity related to exopolysaccharide biosynthesis in fed-batch cultures .

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