By Mario Maj, Hagop S. Akiskal, Juan José López-Ibor Jr., Norman Sartorius
Bipolar sickness is a significant psychological disease concerning episodes of significant mania and melancholy and impacts nearly one to 3 percentage of the inhabitants. in keeping with the nationwide Institute of psychological wellbeing and fitness approximately million members within the usa on my own are clinically determined with this disease.
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Extra info for Bipolar Disorder
Suffice it to say that the ``sunny'' or positive features of hypomania are observed primarily among those with sporadic hypomania. Both the Memphis and Zurich observations are based on individuals who had never been hospitalized for mania, and thus capture the rich phenomenology for hypomania beyond the narrow band criteria in DSM-IV. Also, both studies stipulated a modal duration of two days. This threshold has been recently validated in an Italian study : indeed, nearly all patients in a large consecutive series of private outpatients had hypomania less than four days, and nearly all were recurrent.
Many of these cyclothymic students developed depressive and/or suicidal crisesÐoften in association with substance abuseÐduring prospective observation, underscoring the public health importance of cyclothymia as a putative bipolar diathesis. The General Behavior Inventory (GBI), which has derived from this body of work, has not proven to be particularly useful for clinical practice. Its research applications have been more promising. For instance, high GBI cyclothymia scores have been reported in the offspring of bipolar probands .
3, Akiskal et al  ! 2, and Swann et al  ! 1 depressive symptoms in the midst of mania for the diagnosis of dysphoric mania. These are not mere nosologic exercises, because even one depressive symptom during mania has been reported to predict low response to lithium and good response to divalproex . Mixed mania also appears to respond well to atypical antipsychotics such as olanzapine . CLASSIFICATION, DIAGNOSIS AND BOUNDARIES 27 T a b l e 1 . 1 1 Discriminatory depressive signs and symptoms in the diagnosis of dysphoric mania (based on McElroy et al ; Bauer et al ; Cassidy et al ; Akiskal et al ) .