Download Cascade Biocatalysis Integrating Stereoselective and by Sergio Riva, Wolf-Dieter Fessner PDF

By Sergio Riva, Wolf-Dieter Fessner

This prepared reference offers environmentally pleasant and stereoselective equipment of recent biocatalysis. The skilled and popular group of editors have accrued most sensible foreign authors for this e-book. They conceal such rising subject matters as chemoenzymatic tools and multistep enzymatic reactions, whereas exhibiting how those novel equipment and ideas can be utilized for functional functions. Multidisciplinary issues, together with directed evolution, dynamic kinetic answer, and continuous-flow technique also are discussed.

From the contents:
* Directed Evolution of Ligninolytic Oxidoreductases: from useful Expression to Stabilization and Beyond
* New developments within the In Situ Enzymatic Recycling of NAD(P)(H) Cofactors
* Monooxygenase-Catalyzed Redox Cascade Biotransformations
* Biocatalytic Redox Cascades regarding w-Transaminases
* Multi-Enzyme platforms and Cascade Reactions concerning Cytochrome P450 Monooxygenases
* Chemo-Enzymatic Cascade Reactions for the Synthesis of Glycoconjugates
* Synergies of Chemistry and Biochemistry for the creation of Beta-Amino Acids
* Racemizable Acyl Donors for Enzymatic Dynamic Kinetic Resolution
* Stereoselective Hydrolase-Catalyzed techniques in Continuous-Flow Mode
* views on Multienzyme technique Technology
* Nitrile changing Enzymes interested by ordinary and artificial Cascade Reactions
* Mining Genomes for Nitrilases
* Key-Study at the Kinetic points of the In-Situ NHase/AMase Cascade method of M. imperiale Resting Cells for Nitrile Bioconversion
* Enzymatic Stereoselective Synthesis of Beta-Amino Acids
* New purposes of Transketolase: Cascade Reactions for Assay Development
* Aldolases as Catalyst for the Synthesis of Carbohydrates and Analogs
* Enzymatic iteration of Sialoconjugate Diversity
* Methyltransferases in Biocatalysis
* Chemoenzymatic Multistep One-Pot Processes

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Additional info for Cascade Biocatalysis Integrating Stereoselective and Environmentally Friendly Reactions

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J. and Sun, L. (2010) Creating designer laccases. Chem. , 27, 918–920. , and Alcalde, M. (2013) Blood tolerant laccase by directed evolution. Chem. , 20, 223–231. H. (2002) Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase. Nat. , 20, 1135–1139. H. (2003) Regioand enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3. J. Am. Chem. , 125, 13442–13450. H. (2007) Engineered alkanehydroxylating cytochrome P450BM3 exhibiting nativelike catalytic properties.

47) in the presence of their respective substrates, that is, formate and glucose. In fact, in the last decades, they have been employed most in different reductive reactions, from a laboratory scale up to an industrial scale [2]. Both systems share the advantage of using practically irreversible reactions on cheap co-substrates, being thus suitable for strongly driving the reaction equilibrium of reversible reactions, for example, those catalyzed by ADHs, toward product formation under economically acceptable conditions.

Moreover, the co-product formed in the coupled reaction should be easily separated from the target product. In this chapter, an overview of the more recent attempts of solving the limitations of the already established enzymatic recycling methods will be provided, together with some selected examples of conceptually novel systems. 47) in the presence of their respective substrates, that is, formate and glucose. In fact, in the last decades, they have been employed most in different reductive reactions, from a laboratory scale up to an industrial scale [2].

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