Download Chromatographic and Membrane Processes in Biotechnology by Carlos A. V. Costa (auth.), Carlos A. Costa, Joaquim S. PDF

By Carlos A. V. Costa (auth.), Carlos A. Costa, Joaquim S. Cabral (eds.)

Separation techniques in biotechnology are of accelerating business significance on account that they entail the most important bills of bioprocessing specifically while excessive purity is needed. Chromatography and membranes are of an important applied sciences used for direct therapy of fermentation broths in addition to for prime answer steps in product purification. The theoretical foundations of chromatographic and membrane methods are good understood for the case of small molecules. however there's a have to adapt and extra enhance that wisdom to the processing of huge organic molecules. this can be being completed with the contribution of different parts like molecular biology and fabrics technology. the target of this NATO complicated learn Institute is to provide an up-to-date remedy of the basics of chromatographic and membrane techniques with distinct relevance in bioprocessing.This quantity collects the lectures awarded at this Institute. The lectures are prepared in 5 chapters. bankruptcy I offers with chromatographic methods protecting themes like equilibrium, kinetics and contacting units. Membrane techniques and a few purposes in biotechnology are taken care of in bankruptcy 2. bankruptcy three is dedicated to affinity chromatographic and membrane methods. bankruptcy four considers the present advancements on chromatographic helps and membranes either from the constitutive fabrics and shape issues of view. Scale-up, optimization and reaction/separation integration are the themes coated in bankruptcy five. we're very thankful to all teachers and members that made attainable this Institute. monetary aid from NATO clinical Affairs department, INIC, JNICT, FLAD, collage of Ac;ores and DRT Ac;ores is gratefully acknowledged.

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1990) 'The Moving Finite Element Method with Polynomial Approximation of Any Degree, Compo & Chern. (1), 25-33. [51] Nir, A. and Pismen, L. (1977) 'Simultaneous intraparticle forced convection, diffusion and reaction in a porous catalyst', Chern. Eng. , 32, 35-41. , Orfilo, J. and Zoulalian, A. ntraparticle convection, diffusion and zero-order reaction in porous catalysts', Chern. Eng. , 21,327337. E. Q. (1988) 'Convection, diffusion and reaction in a large-pore catalyst particle', AIChE Symp.

25] Aris R. and Amundson N. (1973) Mathematical Methods in Chemical Engineering. Vol 2 - First-Order Partial differential Equations, Prentice-Hall. [26] Venneulen, T. (1958) 'Separation by adsorption methods', Adv. Chem. , ~, 147-205. [27] Helfferich, F. and Klein, G. (1970) Multicomponent Chromatography, M. Dekker. C. (1986) Large Scale Adsorption and Chromatography, CRC Press. [29] Ruthven, D. (1984) Principles 0/ Adsorption and Adsorption Processes, J. Wiley. [30] Yang, RT. (1987) Gas Separation by Adsorption Processes, Butterworths.

The overall _ mS m map c1 bed transfer function is (33) The influence of the number of mixing cells J and mass transfer kinetics on the chromatographic peak are shown in Figure 15. The moments of the chromatographic peak are now t =tr=1:(1 +k) and ~: - j + 12:k t~ . The first term shows the effect of axial dispersion and the second term shows the contribution of mass transfer kinetics. 2. The continuous theory o/Van Deemter, Zuiderweg and Klinkenberg The continuous approach for chromatographic processes [45] in the case of instantaneous mass transfer and plug flow leads to the overall transfer function G(s)=exp[-s't(1+k)].

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