By Mauricio Tohen
This useful reference explores the comorbidity of melancholy and bipolar problems, addressing themes equivalent to epidemiology, therapy suggestions, and the organization of comorbidity and consequence. makes a speciality of conceptual, empirical, methodological, and modeling matters! contemplating temporal priorities within the predictive relationships among comorbid issues, Comorbidity in Affective issues ·presents facts at the effects of comorbidity for direction and severity ·outlines the results of significant Depressive ailment, grief, and signs of clinical ailment such as melancholy ·highlights the neurochemistry, neuroendocrinology, and neuroimmunology of melancholy ·reviews somatic remedies similar to temper stabilizers, antidepressants, and psychostimulants ·evaluates the position of melancholy in epilepsy, a number of sclerosis, Parkinson's sickness, HIV, and melanoma ·details the hyperlink among melancholy and character from psychodynamic, methodological, and therapy views ·analyzes the results of comorbidity in teenagers, children, and the aged ·ponders destiny instructions for therapy and examine ·and extra! With over 900 references, tables, and drawings, Comorbidity in Affective issues is acceptable for psychiatrists, psychopharmacologists, psychologists, pharmacologists, medical neurologists, neurobiologists, biologists and biochemists, pharmaceutical and behavioral scientists, and scientific and graduate scholars in those disciplines.
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Additional info for Comorbidity in affective disorders
George, is entitled “Depression and Substance Abuse” and describes the epidemiological risk and treatment factors associated with the use of alcohol and illicit drugs by patients with major depression. A parallel chapter in the bipolar disorder section entitled ‘‘Bipolar Disorder and Substance Abuse” (Chapter 7) is by Susan C. Sonne and Kathleen T. Brady. “Depression in the Medically Ill” (Chapter 3), by Jeffrey Newport and Charles B. Nemeroff, and “The Co-occurrence of Bipolar Disorder with Medical Illness” (Chapter 8), authored by Kenji W.
The results showed that first onset of both manic and depressive episodes usually occurred after the prior onset of some other comorbid disorder. Consistent with this finding, our survival analysis showed that prior disorders are associated with an increased risk of the subsequent onset of both MDD and BPI. The analysis of same-year and time-lagged associations between MDD and prior disorders was motivated by the results of an earlier investigation of comorbid PTSD in the NCS, where we found that many of the people who experienced a traumatic event such as rape or assault responded not only by developing PTSD but also by experiencing their first episodes of depression, panic, agoraphobia, or substance abuse (46,47).
In contrast, the focus of our analy-sis was on lifetime consequences. We found that comobidity is consistently associated with the persistence of depression and mania. It is noteworthy that we have elsewhere found that comorbid depression and mania are not consistently associated with the persistence of any of the anxiety disorders (9,72). This asym-metry is inconsistent with a purely genetic hypothesis, but is consistent with the notion, mentioned earlier, that secondary depression might be a severity marker of chronic anxiety linked to exhaustion and demoralization (53,65).